Effect of concomitant or very early statin administration on in-hospital mortality and reinfarction in patients with acute myocardial infarction

被引：43

作者：

Bybee, KA

Wright, RS

Williams, BA

Murphy, JG

Holmes, DR

Kopecky, SL

机构：

[1] Mayo Clin & Mayo Fdn, Mayo Phys Alliance Clin Trials, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Internal Med, Div Cardiovasc Dis, Biostat Sect, Rochester, MN 55905 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 87卷 / 06期

关键词：

D O I：

10.1016/S0002-9149(00)01501-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a retrospective analysis, 66 patients identified as having received a statin drug within 24 hours of admission for acute myocardial infarction were matched 3:1 with a control group of 198 patients not treated with a statin agent. End points of in-hospital mortality and in-hospital reinfarction were significantly lower in the statin-treated group, pointing to a benefit from very early statin treatment in acute myocardial infarction.

引用

收藏

页码：771 / +

页数：5

相关论文

共 20 条

[1] CHANGES INDUCED BY PRAVASTATIN TREATMENT ON HEMOSTATIC AND FIBRINOLYTIC PATTERNS IN PATIENTS WITH TYPE IIB HYPERLIPOPROTEINEMIA [J].

AVELLONE, G ;

DIGARBO, V ;

CORDOVA, R ;

RANELI, G ;

DESIMONE, R ;

BOMPIANI, G .

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1994, 55 (11) :1335-1344

[2] LOVASTATIN THERAPY IN HYPERCHOLESTEROLEMIA - EFFECT ON FIBRINOGEN, HEMORRHEOLOGIC PARAMETERS, PLATELET ACTIVITY, AND RED-BLOOD-CELL MORPHOLOGY [J].

BEIGEL, Y ;

FUCHS, J ;

SNIR, M ;

GREEN, P ;

LURIE, Y ;

DJALDETTI, M .

JOURNAL OF CLINICAL PHARMACOLOGY, 1991, 31 (06) :512-517

[3] Pravastatin therapy in hyperlipidemia: Effects on thrombus formation and the systemic hemostatic profile [J].

Dangas, G ;

Badimon, JJ ;

Smith, DA ;

Unger, AH ;

Levine, D ;

Shao, JH ;

Meraj, P ;

Fier, C ;

Fallon, JT ;

Ambrose, JA .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (05) :1294-1304

[4] Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes -: The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial [J].

Dupuis, J ;

Tardif, JC ;

Cernacek, P ;

Théroux, P .

CIRCULATION, 1999, 99 (25) :3227-3233

[5] INTERNATIONAL DIAGNOSTIC-CRITERIA FOR ACUTE MYOCARDIAL-INFARCTION AND ACUTE STROKE [J].

GILLUM, RF ;

FORTMANN, SP ;

PRINEAS, RJ ;

KOTTKE, TE .

AMERICAN HEART JOURNAL, 1984, 108 (01) :150-158

[6]

JAY RH, 1993, AM J CARDIOL, V72, P1031

[7] Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae [J].

Kothe, H ;

Dalhoff, K ;

Rupp, J ;

Müller, A ;

Kreuzer, J ;

Maass, M ;

Katus, HA .

CIRCULATION, 2000, 101 (15) :1760-1763

[8] HYPERLIPIDEMIA AND CORONARY-DISEASE - CORRECTION OF THE INCREASED THROMBOGENIC POTENTIAL WITH CHOLESTEROL REDUCTION [J].

LACOSTE, L ;

LAM, JYT ;

HUNG, J ;

LETCHACOVSKI, G ;

SOLYMOSS, CB ;

WATERS, D .

CIRCULATION, 1995, 92 (11) :3172-3177

[9]

Lacoste Lucie, 1996, Journal of the American College of Cardiology, V27, p413A

[10] EFFECTS OF LONG-TERM TREATMENT WITH LOVASTATIN ON THE CLOTTING SYSTEM AND BLOOD-PLATELETS [J].

MAYER, J ;

ELLER, T ;

BRAUER, P ;

SOLLEDER, EM ;

SCHAFER, RM ;

KELLER, F ;

KOCHSIEK, K .

ANNALS OF HEMATOLOGY, 1992, 64 (04) :196-201