Antinociceptive activity of Zizyphus spina-christi root bark extract

被引：82

作者：

Adzu, B ^{[1
]}

Amos, S ^{[1
]}

Wambebe, C ^{[1
]}

Gamaniel, K ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Res & Dev, Dept Pharmacol & Toxicol, Garki, Abuja, Nigeria

来源：

FITOTERAPIA | 2001年 / 72卷 / 04期

关键词：

Zizyphus spina-christi; antinociceptive activity;

D O I：

10.1016/S0367-326X(00)00289-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The antinociceptive effect of the aqueous extract of Zizyphus spina-christi root bark was investigated in mice and rats. Acetic acid-induced writhing, formalin and thermal (hot plate) tests were used. The extract (50 and 100 mg/kg, i.p.) showed a dose-dependent analgesic effect in all the tests used. Its i.p. LD50 in mice was 2236.07 mg/kg. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：344 / 350

页数：7

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[No title captured]

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