Psychophysiological measures of (dis)inhibition as liability indicators for schizophrenia

被引:48
作者
Clementz, BA [1 ]
机构
[1] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
关键词
schizophrenia; P50; suppression; genetics; neuropathology; gamma band response; smooth pursuit; saccades;
D O I
10.1111/1469-8986.3560648
中图分类号
B84 [心理学];
学科分类号
04 [教育学]; 0402 [心理学];
摘要
Two psychophysiological measures, poor suppression of midlatency auditory-evoked responses in a paired stimulus paradigm and ocular motor abnormalities, may index genetic liability for schizophrenia. An important feature of these measures is that both patients and their nonpsychotic relatives exhibit basically the same performance. These measures may be successful endophenotypes for schizophrenia because they assess poor response inhibition associated with dysfunction of dorsolateral prefrontal cortex circuitry. Data bearing on this hypothesis are reviewed, and it is posited that assessment of the auditory-evoked gamma band response and saccade measures of inhibitory abilities are the most valid behavioral measures of schizophrenia's neuropathological correlates. The extant data suggest that psychophysiological studies of schizophrenia can provide consistent and theoretically meaningful information for localizing neuropathology and for assessing the genetics of this complex disorder.
引用
收藏
页码:648 / 668
页数:21
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