Functional study of antibodies against a fibrogenin-binding protein in Staphylococcus epidermidis adherence to polyethylene catheters

被引：29

作者：

Pei, L ^{[1
]}

Flock, JI ^{[1
]}

机构：

[1] Huddinge Univ Hosp F82, Karolinska Inst, Dept Immunol Pathol & Microbiol, Div Clin Bacteriol, S-14186 Huddinge, Sweden

来源：

JOURNAL OF INFECTIOUS DISEASES | 2001年 / 184卷 / 01期

关键词：

D O I：

10.1086/321003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Staphylococcus epidermidis is an important pathogen in foreign body-associated infections. In a previous study, we showed that a surface-located fibrinogen-binding protein, termed Fbe, from S. epidermidis mediated the bacterial adherence to fibrinogen-coated surfaces in vitro. In the present study, we demonstrate that antibodies against Fbe can block adherence of S. epidermidis to fibrinogen-coated catheters, subcutaneously implanted catheters from rats, and peripheral venous catheters from human patients.

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页码：52 / 55

页数：4

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