Sex in Plasmodium:: a sign of commitment

被引：61

作者：

Dixon, Matthew W. A. ^{[1
]}

Thompson, Joanne ^{[2
]}

Gardiner, Donald L. ^{[1
]}

Trenholme, Katharine R. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Malaria Biol Lab, Herston, Qld 4006, Australia

[2] Univ Edinburgh, Ashworth Labs, Inst Infect & Immunol Res, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

TRENDS IN PARASITOLOGY | 2008年 / 24卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.pt.2008.01.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The gametocyte, or sexual blood-stage, of the malaria parasite represents the only stage of the parasite that can be transmitted to the mosquito vector following sexual development within the infected bloodmeal. Little is known about the processes leading to this cellular differentiation and specialization. The recent completion of the Plasmodium genome, and subsequent transcriptome and proteome analyses have revealed for the first time a molecular map of the genes that are differentially regulated at the onset of and during gametocytogenesis. In this review, we outline the underlying mechanisms involved in this process, focusing on the transition between the asexual and the sexual blood-stages of the parasite.

引用

页码：168 / 175

页数：8

共 75 条

[1] PLASMODIUM-FALCIPARUM - PARASITES DEFECTIVE IN EARLY STAGES OF GAMETOCYTOGENESIS [J].

ALANO, P ;

ROCA, L ;

SMITH, D ;

READ, D ;

CARTER, R ;

DAY, K .

EXPERIMENTAL PARASITOLOGY, 1995, 81 (02) :227-235

[2] Purine nucleotide cyclases in the malaria parasite [J].

Baker, DA ;

Kelly, JM .

TRENDS IN PARASITOLOGY, 2004, 20 (05) :227-232

[3] MAPPING THE GENETIC-LOCUS IMPLICATED IN CYTOADHERENCE OF PLASMODIUM-FALCIPARUM TO MELANOMA-CELLS [J].

BARNES, DA ;

THOMPSON, J ;

TRIGLIA, T ;

DAY, K ;

KEMP, DJ .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1994, 66 (01) :21-29

[4] Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite [J].

Billker, O ;

Dechamps, S ;

Tewari, R ;

Wenig, G ;

Franke-Fayard, B ;

Brinkmann, V .

CELL, 2004, 117 (04) :503-514

[5] A gene-family encoding small exported proteins is conserved across Plasmodium genus [J].

Birago, C ;

Albanesi, V ;

Silvestrini, F ;

Picci, L ;

Pizzi, E ;

Alano, P ;

Pace, T ;

Ponzi, M .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2003, 126 (02) :209-218

[6] Pfsbp 1, a Maurer's cleft Plasmodium falciparum protein, is associated with the erythrocyte skeleton [J].

Blisnick, T ;

Eugenia, M ;

Betoulle, M ;

Barale, JC ;

Uzureau, P ;

Berry, L ;

Desroses, S ;

Fujioka, H ;

Mattei, D ;

Breton, CB .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2000, 111 (01) :107-121

[7] COMMITMENT OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM TO SEXUAL AND ASEXUAL DEVELOPMENT [J].

BRUCE, MC ;

ALANO, P ;

DUTHIE, S ;

CARTER, R .

PARASITOLOGY, 1990, 100 :191-200

[8] Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro [J].

Buckling, A ;

Ranford-Cartwright, LC ;

Miles, A ;

Read, AF .

PARASITOLOGY, 1999, 118 :339-346

[9] The effect of partial host immunity on the transmission of malaria parasites [J].

Buckling, A ;

Read, AF .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2001, 268 (1483) :2325-2330

[10]

Christensen ST, 1998, INT REV CYTOL, V177, P181

← 1 2 3 4 5 6 7 8 →