Fire in the hole: pore dilation of the capsaicin receptor TRPV1

被引:35
作者
Bautista, Diana [1 ]
Julius, David [1 ]
机构
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
关键词
D O I
10.1038/nn0508-528
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The capsaicin receptor TRPV1 is important in pain sensation. A new study suggests that this nonselective cation channel shows dynamic alterations in ion permeability, which may contribute to mechanisms of pain hypersensitivity.
引用
收藏
页码:528 / 529
页数:3
相关论文
共 11 条
[1]
Binshtok AM, 2007, NATURE, V449, P607, DOI 10.1038/nature06191
[2]
Impaired nociception and pain sensation in mice lacking the capsaicin receptor [J].
Caterina, MJ ;
Leffler, A ;
Malmberg, AB ;
Martin, WJ ;
Trafton, J ;
Petersen-Zeitz, KR ;
Koltzenburg, M ;
Basbaum, AI ;
Julius, D .
SCIENCE, 2000, 288 (5464) :306-313
[3]
TRPV1 shows dynamic ionic selectivity during agonist stimulation [J].
Chung, Man-Kyo ;
Gueler, Ali D. ;
Caterina, Michael J. .
NATURE NEUROSCIENCE, 2008, 11 (05) :555-564
[4]
Density-dependent changes of the pore properties of the P2X2 receptor channel [J].
Fujiwara, Y ;
Kubo, Y .
JOURNAL OF PHYSIOLOGY-LONDON, 2004, 558 (01) :31-43
[5]
PHARMACOLOGICALLY INDUCED SELECTIVE DEGENERATION OF CHEMOSENSITIVE PRIMARY SENSORY NEURONS [J].
JANCSO, G ;
KIRALY, E ;
JANCSOGABOR, A .
NATURE, 1977, 270 (5639) :741-743
[6]
Molecular mechanisms of nociception [J].
Julius, D ;
Basbaum, AI .
NATURE, 2001, 413 (6852) :203-210
[7]
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds [J].
Khakh, BS ;
Bao, XR ;
Labarca, C ;
Lester, HA .
NATURE NEUROSCIENCE, 1999, 2 (04) :322-330
[8]
Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex [J].
Locovei, Silviu ;
Scemes, Eliana ;
Qiu, Feng ;
Spray, David C. ;
Dahl, Gerhard .
FEBS LETTERS, 2007, 581 (03) :483-488
[9]
Meyers JR, 2003, J NEUROSCI, V23, P4054
[10]
Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor [J].
Pelegrin, Pablo ;
Surprenant, Annmarie .
EMBO JOURNAL, 2006, 25 (21) :5071-5082