Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria

被引:135
作者
Djimdé, A
Doumbo, OK
Steketee, RW
Plowe, CV [1 ]
机构
[1] Univ Maryland, Sch Med, Ctr Vaccine Dev, Malaria Sect, Baltimore, MD 21201 USA
[2] Univ Mali, Fac Med Pharm & Dent, Dept Epidemiol & Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali
[3] NIAID, Malaria Genet Sect, Parasit Dis Lab, Bethesda, MD 20892 USA
[4] Ctr Dis Control & Prevent, Malaria Epidemiol Branch, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA USA
关键词
D O I
10.1016/S0140-6736(01)06040-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Drug-resistant falciparum malaria is increasing in Africa and so methods to map resistance on a broad scale are needed. A molecular marker for chloroquine resistance, pfcrt T76, can be used for surveillance of clinical chloroquine resistance. The prevalence of pfcrt T76 and the prevalence of clinical chloroquine resistance and therapeutic failure were measured at sentinel sites and used to calculate age-adjusted genotype-resistance Indices (GRIs) and genotype-failure Indices (GFIs). We found stable GRIs and GFIs at different sites In Mail, West Africa. This model permits mapping of chloroquine resistance using molecular tools in rapid and simple cross-sectional surveys.
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收藏
页码:890 / 891
页数:2
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