Bioreduction of 2-oxocyclopentanecarboxamides:: syntheses of optically active 2-aminomethyl- and 2-aminocyclopentanols

被引：18

作者：

Quirós, M ^{[1
]}

Rebolledo, F ^{[1
]}

Gotor, V ^{[1
]}

机构：

[1] Univ Oviedo, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(99)00016-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The fungus Mortierella isabellina NRRL 1757 catalyzes the reduction of 2-oxocyclopentanecarboxamides with very high enantioselectivity giving, in most cases, the corresponding enantiopure 2-hydroxycyclopentanecarboxamides. The presence or absence of a substituent on the amidic nitrogen has a strong influence on the diastereoselectivity achieved in these processes. Optically active hydroxyamides prepared in these microbial reductions are used as starting materials for the preparation of optically active 2-aminomethyl- and 2-aminocyclopentanols. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：473 / 486

页数：14

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