Regulation of thermogenesis by the central melanocortin system

被引：59

作者：

Fan, W

Voss-Andreae, A

Cao, WH

Morrison, SF

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Ctr Study Weight Regulat & Assoc Disorders, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Inst Neurol Sci, Beaverton, OR 97006 USA

来源：

PEPTIDES | 2005年 / 26卷 / 10期

关键词：

obesity; melanocortin; POMC; AGRP; thermogenesis; sympathetic nervous system; BAT; UCP; thyroid; central circuits; diet-induced thermogenesis; pathogenic stimuli;

D O I：

10.1016/j.peptides.2004.11.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adaptive thermogenesis represents one of the important homeostatic mechanisms by which the body maintains appropriate levels of stored energy and its core temperature. Dysregulation of adaptive thermogenesis promotes obesity. The central melanocortin system, in particular the melanocortin 4 receptor (MC4R) signaling pathway, influences the regulation of every aspect of energy balance, including thermogenesis, and plays a critical role in energy homeostasis in both rodent and man. This review will outline our current understanding of adaptive thermogenesis, focusing on the role of the central melanocortin pathway in the regulation of thermogenesis. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1800 / 1813

页数：14

共 180 条

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