Regional expression of mRNA encoding a second form of gonadotropin-releasing hormone in the macaque brain

被引:12
作者
Urbanski, HF
White, RB
Fernald, RD
Kohama, SG
Garyfallou, VT
Densmore, VS
机构
[1] Oregon Reg Primate Res Ctr, Div Neurosci, Beaverton, OR 97006 USA
[2] Oregon Hlth Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA
[3] Stanford Univ, Program Neurosci, Stanford, CA 94305 USA
关键词
D O I
10.1210/en.140.4.1945
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In mammals, reproduction is thought to be controlled by a single neuropeptide, gonadotropin-releasing hormone (GnRH-I), which regulates the synthesis and secretion of gonadotropins from the pituitary gland. However, another form of this decapeptide (GnRH-II), of unknown function, also exists in the brain of many vertebrate species, including humans; it is encoded by a different gene and its amino acid sequence is 70% identical to that of GnRH-I. Here we report the cloning of a GnRH-II cDNA from the rhesus macaque (Macaca mulatta), and show for the first time by in situ hybridization that GnRH-II mRNA is expressed in the primate midbrain, hippocampus and discrete nuclei of the hypothalamus, including the supraoptic, paraventricular, suprachiasmatic and arcuate. Because the regional distribution pattern of cells containing GnRH-II mRNA is largely dissimilar to that of cells containing GnRH-I mRNA, it is likely that these two cell populations receive distinct neuroendocrine inputs and thus regulate GnRH synthesis and release differently.
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页码:1945 / 1948
页数:4
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