Molecular anatomy of the human glucose 6-phosphate dehydrogenase core promoter

被引：30

作者：

Franzè, A ^{[1
]}

Ferrante, MI ^{[1
]}

Fusco, F ^{[1
]}

Santoro, A ^{[1
]}

Sanzari, E ^{[1
]}

Martini, G ^{[1
]}

Ursini, MV ^{[1
]}

机构：

[1] CNR, Ist Int Genet & Biofis, I-80125 Naples, Italy

来源：

FEBS LETTERS | 1998年 / 437卷 / 03期

关键词：

housekeeping gene; initiator; glucose 6-phosphate dehydrogenase; Sp1;

D O I：

10.1016/S0014-5793(98)01259-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene encoding glucose 6-phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed. (C) 1998 Federation of European Biochemical Societies.

引用

页码：313 / 318

页数：6

共 25 条

[1] TISSUE-SPECIFIC LEVELS OF HUMAN GLUCOSE-6-PHOSPHATE-DEHYDROGENASE CORRELATE WITH METHYLATION OF SPECIFIC SITES AT THE 3' END OF THE GENE [J].