Ethanol-induced expression of c-Fos differentiates the FAST and SLOW selected lines of mice

被引:15
作者
Demarest, K
Hitzemann, B
Phillips, T
Hitzemann, R [1 ]
机构
[1] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA
[3] Vet Adm Med Ctr, Res & Psychiat Serv, Northport, NY 11768 USA
[4] Vet Adm Med Ctr, Res Serv, Portland, OR USA
关键词
ethanol; c-Fos; amygdala; central nucleus; basal ganglia;
D O I
10.1111/j.1530-0277.1999.tb04027.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
The effect of ethanol on the number of Fos-like immunoreactive (Fos-li) neurons was previously studied in the C57BL/6J (B6) and DBA/2J (D2) inbred mouse strains (Hitzemann and Hitzemann, 1997), Data obtained suggested that the locomotor activation response to ethanol found in the D2 but not the B6 strain was associated with an increase in the number of Fos-li neurons (a putative measure of synaptic activity) in the central nucleus of the amygdala (CeA), but not in other brain regions, including the basal ganglia, Supporting results were obtained in B6D2 F-2 intercross animals (Demarest et at., 1998) those animals exhibiting a marked locomotor activation response to ethanol also showed a significant increase in the number of Fos-ii neurons in the CeA, The current study extends this line of investigation to the FAST and SLOW selected lines of mice (Shen et at., 1995), Twenty-eight SLOW and FAST mice (taken evenly from both replicate lines) were randomly assigned to receive either saline or ethanol (1.5 g/kg), One hour later, the animals were sacrificed, and the number of Fos-li neurons were determined using standard immunocytochemical techniques, Both the FAST and SLOW lines showed a marked increase (>300%) in the number of Fos-li neurons in the lateral aspect of the CeA; however, in the capsular division, only the FAST line showed an increase (>500%), In several brain regions, the basal(saline) response was markedly higher in the SLOW line; these regions included the subthalamic nucleus, the entopeduncular nucleus, the substantia nigra compacta, and the ventral tegmental area, Furthermore, it was found that ethanol decreased the number of Fos-li neurons in the ventral tegmental area of the SLOW but not FAST mice. These data suggest a substantial involvement of the basal ganglia in the segregation of the FAST and SLOW lines.
引用
收藏
页码:87 / 95
页数:9
相关论文
共 42 条
[1]  
Alheid George F., 1995, P495
[2]   HISTOFLUORESCENCE ANALYSIS OF SEVERAL SYSTEMS OF CATECHOLAMINERGIC NERVE-FIBERS WITHIN THE RAT NEOSTRIATUM REVEALED BY EITHER RESTRICTED LESIONS OF THE SUBSTANTIA NIGRA OR GAMMA-HYDROXYBUTYRATE [J].
ARLUISON, M ;
JAVOYAGID, F ;
FEUERSTEIN, C ;
TAUC, M ;
CONRATHVERRIER, M ;
MAILLY, P .
BRAIN RESEARCH BULLETIN, 1982, 9 (1-6) :355-365
[3]  
BECK CHM, 1995, J NEUROSCI, V15, P709
[4]   THE MESOLIMBIC DOPAMINE-ACTIVATING PROPERTIES OF ETHANOL ARE ANTAGONIZED BY MECAMYLAMINE [J].
BLOMQVIST, O ;
ENGEL, JA ;
NISSBRANDT, H ;
SODERPALM, B .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 249 (02) :207-213
[5]   HALOPERIDOL PREVENTS ETHANOL-STIMULATED LOCOMOTOR-ACTIVITY BUT FAILS TO BLOCK SENSITIZATION [J].
BROADBENT, J ;
GRAHAME, NJ ;
CUNNINGHAM, CL .
PSYCHOPHARMACOLOGY, 1995, 120 (04) :475-482
[6]  
BRODIE MS, 1995, J PHARMACOL EXP THER, V273, P1139
[7]   ACTIVATION AND DESENSITIZATION OF FOS IMMUNOREACTIVITY IN THE RAT-BRAIN FOLLOWING ETHANOL ADMINISTRATION [J].
CHANG, SL ;
PATEL, NA ;
ROMERO, AA .
BRAIN RESEARCH, 1995, 679 (01) :89-98
[8]   GENETIC-DIFFERENCES IN LOCOMOTOR ACTIVATION IN MICE [J].
CRABBE, JC .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 25 (01) :289-292
[9]   MICE GENETICALLY SELECTED FOR DIFFERENCES IN OPEN-FIELD ACTIVITY AFTER ETHANOL [J].
CRABBE, JC ;
YOUNG, ER ;
DEUTSCH, CM ;
TAM, BR ;
KOSOBUD, A .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (03) :577-581
[10]   BIPHASIC EFFECTS OF ETHANOL ON OPEN-FIELD ACTIVITY - SENSITIVITY AND TOLERANCE IN C57BL/6N AND DBA/2N MICE [J].
CRABBE, JC ;
JOHNSON, NA ;
GRAY, DK ;
KOSOBUD, A ;
YOUNG, ER .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1982, 96 (03) :440-451