Plague bacteria target immune cells during infection

被引：267

作者：

Marketon, MM

DePaolo, RW

DeBord, KL

Jabri, B

Schneewind, O ^{[1
]}

机构：

[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

SCIENCE | 2005年 / 309卷 / 5741期

关键词：

D O I：

10.1126/science.1114580

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted for injection during plague infection is unknown. We found, using Yop beta-lactamase hybrids and fluorescent staining of live cells from plague-infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages, and neutrophils were injected most frequently, whereas B and T lymphocytes were rarely selected. Thus, it appears that Y. pestis disables these cell populations to annihilate host immune responses during plague.

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页码：1739 / 1741

页数：3

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