Neurobiology of attention deficit hyperactivity disorder

被引：91

作者：

Kieling, Christian ^{[1
]}

Goncalves, Renata R. F. ^{[1
]}

Tannock, Rosemary ^{[2
]}

Castellanos, Francisco X. ^{[3
,4
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Psychiat, BR-90035903 Porto Alegre, RS, Brazil

[2] Hosp Sick Children, Neurosci & Mental Hlth Res Program, Toronto, ON M5G 1X8, Canada

[3] NYU, Ctr Child Study, New York, NY 10016 USA

[4] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA

来源：

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA | 2008年 / 17卷 / 02期

关键词：

D O I：

10.1016/j.chc.2007.11.012

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This article addresses the current understanding of the neurobiological bases of attention deficit hyperactivity disorder (ADHD), focusing on empiric research findings that connect genetic and environmental factors to structural and functional brain abnormalities, ultimately leading to a set of age-dependent behavioral manifestations. Section one presents evidence for genetic risk factors for ADHD and discusses the role of potential environmental factors in the etiology of the disorder. Section two focuses on brain imaging studies and how they have helped generate different hypotheses regarding the pathophysiology of ADHD. Finally, the article addresses the longitudinal course of symptoms in ADHD from infancy to adulthood in an attempt to place biological findings for this complex brain disorder in the context of maturation and development.

引用

页码：285 / +

页数：24

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