Update on Wegener granulomatosis

被引:11
作者
Langford, CA [1 ]
机构
[1] Cleveland Clin Fdn, Dept Rheumat & Immunol Dis, Ctr Vasculitis Care & Res, Cleveland, OH 44195 USA
关键词
D O I
10.3949/ccjm.72.8.689
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Wegener granulomatosis classically involves clinical disease of the upper airways, lungs, and kidneys. Ninety percent of patients present with symptoms involving the upper or lower airways, or both, and it should be suspected in any patient with pulmonary hemorrhage, glomerulonephritis, mononeuritis multiplex, unexplained multisystem disease, or progressive unresponsive sinus disease. Current treatments induce remission and allow long-term survival.
引用
收藏
页码:689 / +
页数:9
相关论文
共 40 条
[1]   Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis [J].
Balding, CEJ ;
Howie, AJ ;
Drake-Lee, AB ;
Savage, COS .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2001, 125 (02) :332-339
[2]   Efficacy of the anti-TNF-α antibody infliximab against refractory systemic vasculitides:: an open pilot study on 10 patients [J].
Bartolucci, P ;
Ramanoelina, J ;
Cohen, P ;
Mahr, A ;
Godmer, P ;
Le Hello, C ;
Guillevin, L .
RHEUMATOLOGY, 2002, 41 (10) :1126-1132
[3]  
Boomsma MM, 2000, ARTHRITIS RHEUM-US, V43, P2025, DOI 10.1002/1529-0131(200009)43:9<2025::AID-ANR13>3.0.CO
[4]  
2-O
[5]   Safety and efficacy of TNFα blockade in relapsing vasculitis [J].
Booth, AD ;
Jefferson, HJ ;
Ayliffe, W ;
Andrews, PA ;
Jayne, DR .
ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (06) :559-559
[6]  
Csernok E, 1999, ARTHRITIS RHEUM, V42, P742, DOI 10.1002/1529-0131(199904)42:4<742::AID-ANR18>3.3.CO
[7]  
2-9
[8]   WEGENERS GRANULOMATOSIS - STUDIES IN 18 PATIENTS AND A REVIEW OF LITERATURE [J].
FAUCI, AS ;
WOLFF, SM .
MEDICINE, 1973, 52 (06) :535-561
[9]   WEGENERS GRANULOMATOSIS - PROSPECTIVE CLINICAL AND THERAPEUTIC EXPERIENCE WITH 85 PATIENTS FOR 21 YEARS [J].
FAUCI, AS ;
HAYNES, BF ;
KATZ, P ;
WOLFF, SM .
ANNALS OF INTERNAL MEDICINE, 1983, 98 (01) :76-85
[10]   A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis [J].
Guillevin, L ;
Cordier, JF ;
Lhote, F ;
Cohen, P ;
Jarrousse, B ;
Royer, I ;
Lesavre, P ;
Jacquot, C ;
Bindi, P ;
Bielefeld, P ;
Desson, JF ;
Détrée, F ;
Dubois, A ;
Hachulla, E ;
Hoen, B ;
Jacomy, D ;
Seigneuric, C ;
Lauque, D ;
Stern, M ;
Longy-Boursier, M .
ARTHRITIS AND RHEUMATISM, 1997, 40 (12) :2187-2198