Serotonin receptor 1A-1019C/G variant: Impact on antidepressant pharmacoresponse in melancholic depression?

被引:36
作者
Baune, B. T. [1 ,2 ]
Hohoff, C. [2 ]
Roehrs, T. [2 ]
Deckert, J. [3 ]
Arolt, V. [2 ]
Domschke, K. [2 ]
机构
[1] James Cook Univ, Sch Med, Dept Psychiat, Townsville, Qld 4811, Australia
[2] Univ Munster, Dept Psychiat, D-48143 Munster, Germany
[3] Univ Wuerzberg, Dept Psychiat, D-97080 Wuerburg, Germany
关键词
major depressive episode; melancholic depression; serotonin receptor;
D O I
10.1016/j.neulet.2008.03.001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous studies on the effects of serotonin receptor 1A (5-HT1A) gene variation on treatment response in depression revealed inconsistent results with studies pointing towards a detrimental influence of the 5-HT1A - 1019G allele on antidepressant treatment response, while others did not discern any involvement of 5-HT1A variants. In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A - 1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression). Antidepressant treatment response across 5-HT1A - 1019C/G genotype groups showed no differences in either Major Depressive Episode or major depression between genotype groups, whereas stratification for the melancholic subtype of depression revealed a significantly worse treatment response as conferred by the - 1019CC genotype (p = 0.02). The poorer treatment response in melancholic depression could first be detected in week 2 (p = 0.03), continuing until week 6 and showing a maximum effect in week 3 (p = 0.01). The present study adds to the clarification of the role of 5-HT1A variation in treatment response in major depression by providing preliminary support for poor treatment response mediated by the 5-HT1A - 1019C allele repressing 5-HT1A activity specifically in the melancholic subtype of depression. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:111 / 115
页数:5
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