A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases

被引：38

作者：

Mazzucco, S

Matà, S

Vergelli, M

Fioresi, R

Nardi, E

Mazzanti, B

Chelli, M

Lolli, F

Ginanneschi, D

Pinto, F

Massacesi, L

Papini, AM

机构：

[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50121 Florence, Italy

[2] Univ Florence, CNR, Ctr Studio Chim & Struttura Composti Eterociclici, I-50121 Florence, Italy

[3] Univ Florence, I-50121 Florence, Italy

[4] Univ Florence, Dipartartimento Sci Neurol & Psichiatr, Serv Neurofisiopatol, I-50134 Florence, Italy

[5] Univ Florence, Dipartiemento Sci Neurol & Psichiatr, I-50134 Florence, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期

关键词：

MOG; glycopeptides; multiple sclerosis; antibodies;

D O I：

10.1016/S0960-894X(98)00698-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side-chains of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hMOG(30-50) and to its glucoderivatives were measured by ELISA in sera of patients affected by different neurological diseases. Anti-hMOG(30-50) antibodies were detected only using the glycopeptide [Asn(31)(N-Glc)]hMOG(30-50). (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：167 / 172

页数：6

相关论文

共 13 条

[1] SYNTHESIS OF GLYCOSYLATED HYDROXYPROLINE BUILDING-BLOCKS [J].

ARSEQUELL, G ;

SARRIES, N ;

VALENCIA, G .

TETRAHEDRON LETTERS, 1995, 36 (40) :7323-7326

[2] Myelin oligodendrocyte glycoprotein: A novel candidate autoantigen in multiple sclerosis [J].

Bernard, CCA ;

Johns, TG ;

Slavin, A ;

Ichikawa, M ;

Ewing, C ;

Liu, J ;

Bettadapura, J .

JOURNAL OF MOLECULAR MEDICINE-JMM, 1997, 75 (02) :77-88

[3] PROTECTED-MODE SYNTHESIS OF N-LINKED GLYCOPEPTIDES - SINGLE-STEP PREPARATION OF BUILDING-BLOCKS AS PERACETYL GLYCOSYLATED N-ALPHA-FMOC ASPARAGINE OPFP ESTERS [J].

CHRISTIANSENBRAMS, I ;

MELDAL, M ;

BOCK, K .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (13) :1461-1471

[4] REACTIVITY TO MYELIN ANTIGENS IN MULTIPLE-SCLEROSIS - PERIPHERAL-BLOOD LYMPHOCYTES RESPOND PREDOMINANTLY TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN [J].

DEROSBO, NK ;

MILO, R ;

LEES, MB ;

BURGER, D ;

BERNARD, CCA ;

BENNUN, A .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (06) :2602-2608

[5] MYELIN OLIGODENDROCYTE GLYCOPROTEIN IS A UNIQUE MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY [J].

GARDINIER, MV ;

AMIGUET, P ;

LININGTON, C ;

MATTHIEU, JM .

JOURNAL OF NEUROSCIENCE RESEARCH, 1992, 33 (01) :177-187

[6] Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate [J].

Genain, CP ;

Nguyen, MH ;

Letvin, NL ;

Pearl, R ;

Davis, RL ;

Adelman, M ;

Lees, MB ;

Linington, C ;

Hauser, SL .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (06) :2966-2974

[7]

Ichikawa M, 1996, J IMMUNOL, V157, P919

[8] T-CELLS SPECIFIC FOR THE MYELIN OLIGODENDROCYTE GLYCOPROTEIN MEDIATE AN UNUSUAL AUTOIMMUNE INFLAMMATORY RESPONSE IN THE CENTRAL-NERVOUS-SYSTEM [J].

LININGTON, C ;

BERGER, T ;

PERRY, L ;

WEERTH, S ;

HINZESELCH, D ;

ZHANG, YP ;

LU, HC ;

LASSMANN, H ;

WEKERLE, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (06) :1364-1372

[9] Glycosyl derivatives of NK2 tachykinin receptor antagonists [J].

Pinzani, D ;

Papini, AM ;

Vallecchi, ME ;

Chelli, M ;

Ginanneschi, M ;

Rapi, G ;

Quartara, L ;

Patacchini, R ;

Maggi, CA ;

Arcamone, FM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (04) :367-372

[10] SMALL-SCALE SOLID-PHASE O-GLYCOPEPTIDE SYNTHESIS OF LINEAR AND CYCLIZED HEXAPEPTIDES FROM BLOOD-CLOTTING FACTOR-IX CONTAINING O-(ALPHA-D-XYL-1-]3-ALPHA-D-XYL-1-]3-BETA-D-GLC)-L-SER [J].

REIMER, KB ;

MELDAL, M ;

KUSUMOTO, S ;

FUKASE, K ;

BOCK, K .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (08) :925-932