A molecular clutch disables flagella in the Bacillus subtilis biofilm

被引：242

作者：

Blair, Kris M. ^{[1
]}

Turner, Linda ^{[2
]}

Winkelman, Jared T. ^{[1
]}

Berg, Howard C. ^{[2
,3
]}

Kearns, Daniel B. ^{[1
]}

机构：

[1] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

[2] Rowland Inst Sci Inc, Cambridge, MA 02142 USA

[3] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

SCIENCE | 2008年 / 320卷 / 5883期

关键词：

D O I：

10.1126/science.1157877

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Biofilms are multicellular aggregates of sessile bacteria encased by an extracellular matrix and are important medically as a source of drug- resistant microbes. In Bacillus subtilis, we found that an operon required for biofilm matrix biosynthesis also encoded an inhibitor of motility, EpsE. EpsE arrested flagellar rotation in a manner similar to that of a clutch, by disengaging motor force-generating elements in cells embedded in the biofilm matrix. The clutch is a simple, rapid, and potentially reversible form of motility control.

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页码：1636 / 1638

页数：3

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