Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee

被引：183

作者：

Tanaka, N ^{[1
]}

Sakahashi, H ^{[1
]}

Sato, E ^{[1
]}

Hirose, K ^{[1
]}

Ishima, T ^{[1
]}

Ishii, S ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Orthopaed Surg, Sapporo, Hokkaido, Japan

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2001年 / 83B卷 / 05期

关键词：

D O I：

10.1302/0301-620X.83B5.11745

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We studied 99 patients who were undergoing total knee arthroplasty (TKA) to determine the optimum protocol for the administration of tranexamic acid (TNA) in order to reduce blood loss. It decreased by more than 40% after the administration of TNA, The haemostatic effect was greatest when TNA was given preoperatively and on deflation of the tourniquet, There was no increase in the incidence of adverse affects in the patients receiving TNA, compared with a control group. We conclude that two injections of TNA, one given preoperatively and one on deflation of the tourniquet, significantly reduce blood loss without increasing the risk of thromboembolic complications.

引用

页码：702 / 705

页数：4

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