Fragrances and other materials in deodorants:: search for potentially sensitizing molecules using combined GC-MS and structure activity relationship (SAR) analysis

被引:44
作者
Rastogi, SC
Lepoittevin, JP
Johansen, JD
Frosch, PJ
Menné, T
Bruze, M
Dreier, B
Andersen, KE
White, IR
机构
[1] Natl Environm Res Inst, Dept Environm Chem, DK-4000 Roskilde, Denmark
[2] Univ Strasbourg, CNRS, Lab Dermatochim, Strasbourg, France
[3] Univ Copenhagen, Gentofte Hosp, Dept Dermatol, Copenhagen, Denmark
[4] Der Stadt Kliniken, Dept Dermatol, Dortmund, Germany
[5] Univ Witten Herdecke, D-5810 Witten, Germany
[6] Malmo Univ Hosp, Dept Occupat Dermatol, Malmo, Sweden
[7] Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark
[8] St Johns Inst Dermatol, London, England
关键词
contact allergy; deodorants; fragrances; non-fragrance substances; gas chromatography - mass spectrometry; structure-activity relationships; chemical analysis; prevention; cosmetics;
D O I
10.1111/j.1600-0536.1998.tb05944.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Deodorants are one of the most frequently-used types of cosmetics and are a source of allergic contact dermatitis. Therefore, a gas chromatography - mass spectrometric analysis of 71 deodorants was performed for identification of fragrance and non-fragrance materials present in marketed deodorants. Futhermore, the sensitizing potential of these molecules was evaluated using structure activity relationships (SARs) analysis. This was based on the presence of 1 or more chemically reactive site(s), in the chemical structure, associated with sensitizing potential. Among the many different substances used to formulate cosmetic products (over 3500), 226 chemicals were identified in a sample of 71 deodorants. 84 molecules were found to contain at least 1 structural alert, and 70 to belong to, or be susceptible to being metabolized into, the chemical group of aldehydes, ketones and alpha,beta-unsaturated aldehydes, ketone or esters. The combination of GC-MS and SARs analysis could be helpful in the selection of substances for supplementary investigations regarding sensitizing properties. Thus, it may be a valuable tool in the management of contact allergy to deodorants and for producing new deodorants with decreased propensity to cause contact allergy.
引用
收藏
页码:293 / 303
页数:11
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