NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity

被引：274

作者：

Ali, DW

Salter, MW ^{[1
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Physiol, Programme Brain & Behav & Cell Biol, Toronto, ON M5G 1X8, Canada

[2] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 03期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/S0959-4388(00)00216-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regulation of postsynaptic glutamate receptors is one of the main mechanisms for altering synaptic efficacy in the central nervous system. Recent studies have given insight into the upregulation of the NMDA receptor by Src family tyrosine kinases, which bind to scaffolding proteins in the NMDA receptor complex. Src acts as a common step in signalling cascades that link G-protein-coupled receptors with protein kinase C via the intermediary cell-adhesion kinase P. This signalling to NMDA receptors is required for long-term potentiation in the CA1 region of the hippocampus.

引用

页码：336 / 342

页数：7

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