Polymer translocation through a nanopore. II. Excluded volume effect

被引:104
作者
Kong, CY [1 ]
Muthukumar, M [1 ]
机构
[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA
关键词
D O I
10.1063/1.1642588
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Following our previous study of a Gaussian chain translocation, we have investigated the transport of a self-avoiding chain from one sphere to another sphere through a narrow pore, using the self-consistent field theory formalism. The free energy landscape for polymer translocation is significantly modified by excluded volume interactions among monomers. The free energy barrier for the placement of one of the chain ends at the pore depends on the chain length N nonmonotonically, in contrast to the N-independence for Gaussian chains. This results in a nonmonotonic dependence of the average arrival time <tau(0)> on N for self-avoiding chains. When the polymer chain is partitioned between the donor and recipient spheres, a local free energy minimum develops, depending on the strength w of the excluded volume interaction and the relative sizes of the donor and recipient spheres. If the sizes of spheres are comparable, the average translocation time <tau> (the average time taken by the polymer, after the arrival at the pore, to convert from the donor to the recipient) increases with an increase in w for a fixed N value. On the other hand, for the highly asymmetric sizes of the donor and recipient spheres, <tau> decreases with an increase in w. As in the case of Gaussian chains, <tau> depends nonmonotonically on the pore length. (C) 2004 American Institute of Physics.
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页码:3460 / 3466
页数:7
相关论文
共 31 条
[1]  
Alberts B., 1994, MOL BIOL CELL
[2]   Charged polymer membrane translocation [J].
Ambjörnsson, T ;
Apell, SP ;
Konkoli, Z ;
Di Marzio, EA ;
Kasianowicz, JJ .
JOURNAL OF CHEMICAL PHYSICS, 2002, 117 (08) :4063-4073
[3]   Three-dimensional dynamic Monte Carlo simulations of driven polymer transport through a hole in a wall [J].
Chern, SS ;
Cárdenas, AE ;
Coalson, RD .
JOURNAL OF CHEMICAL PHYSICS, 2001, 115 (16) :7772-7782
[4]   Anomalous dynamics of translocation [J].
Chuang, J ;
Kantor, Y ;
Kardar, M .
PHYSICAL REVIEW E, 2002, 65 (01) :1-011802
[5]   Phase transition behavior of a linear macromolecule threading a membrane [J].
DiMarzio, EA ;
Mandell, AJ .
JOURNAL OF CHEMICAL PHYSICS, 1997, 107 (14) :5510-5514
[6]  
Doi M., 1986, THEORY POLYM DYNAMIC
[7]   THEORY OF STABILIZATION OF COLLOIDS BY ADSORBED POLYMER [J].
DOLAN, AK ;
EDWARDS, SF .
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 1974, 337 (1611) :509-516
[8]   STATISTICAL MECHANICS OF POLYMERS WITH EXCLUDED VOLUME [J].
EDWARDS, SF .
PROCEEDINGS OF THE PHYSICAL SOCIETY OF LONDON, 1965, 85 (546P) :613-&
[9]   Identification and characterization of a cell membrane nucleic acid channel [J].
Hanss, B ;
Leal-Pinto, E ;
Bruggeman, LA ;
Copeland, TD ;
Klotman, PE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1921-1926
[10]   THEORY OF INTERFACE BETWEEN IMMISCIBLE POLYMERS .2. [J].
HELFAND, E ;
TAGAMI, Y .
JOURNAL OF CHEMICAL PHYSICS, 1972, 56 (07) :3592-&