Concise synthesis of pyrrolophenanthridine alkaloids using a Pd-catalyzed biaryl coupling reaction with regioselective C-H activation

被引：13

作者：

Harayama, T ^{[1
]}

Hori, A ^{[1
]}

Abe, H ^{[1
]}

Takeuchi, Y ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

HETEROCYCLES | 2003年 / 60卷 / 11期

关键词：

DIELS-ALDER REACTIONS; BENZO<C>PHENANTHRIDINE ALKALOIDS; CHEMICAL-CONSTITUENTS; AMARYLLIDACEAE; ARYL; HIPPADINE; PD(OAC)(2); HALIDES; CYCLIZATIONS; KETONES;

D O I：

10.3987/COM-03-9883

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The concise synthesis of the pyrrolophenanthridine alkaloids such as anhydrolycorine, assoanine, anhydrolycorin-7-one, and oxoassoanine, was achieved using the Pd-catalyzed biaryl coupling reaction of 1-(2-halobenzyl)-2,3-dihydroindole by applying the regioselective C-H activation method with intramolecular coordination of the benzylamino group to Pd.

引用

页码：2429 / 2434

页数：6

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