Heparin inhibits retrovirus binding to fibronectin as well as retrovirus gene transfer on fibronectin fragments

被引：11

作者：

Carstanjen, D

Dutt, P

Moritz, T

机构：

[1] Max Delbruck Ctr Mol Med, Berlin, Germany

[2] Canc Res Inst, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

[3] Univ Essen Gesamthsch, Sch Med, W German Canc Ctr, Dept Internal Med Canc Res, Essen, Germany

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 13期

关键词：

D O I：

10.1128/JVI.75.13.6218-6222.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fibronectin fragments have been shown to improve retrovirus gene transfer efficiency by binding retrovirus and target cells. Using a novel virus adhesion assay, we confirmed binding of type C oncoretrovirus vectors to the heparin II domain of fibronectin and demonstrated inhibition of viral binding and gene transfer by heparin.

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收藏

页码：6218 / 6222

页数：5

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