Optical behaviors of ZnO-porphyrin conjugates and their potential applications for cancer treatment

被引：84

作者：

Liu, Yuanfang ^{[2
]}

Zhang, Yongbin ^{[3
]}

Wang, Shaopeng ^{[2
]}

Pope, Carey ^{[3
]}

Chen, Wei ^{[1
]}

机构：

[1] Univ Texas Arlington, Dept Phys, Arlington, TX 76019 USA

[2] ICx Technol Inc, Stillwater, OK 74074 USA

[3] Oklahoma State Univ, Dept Psychol Sci, Stillwater, OK 74078 USA

来源：

APPLIED PHYSICS LETTERS | 2008年 / 92卷 / 14期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.2908211

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

ZnO nanoparticles were synthesized and conjugated to the porphyrin derivative, meso-tetra (o-amino phenyl) porphyrin (MTAP). Energy transfer from the ZnO nanoparticles to MTAP was investigated and the energy transfer rate was measured to be as high as 83%. Compared with MTAP and ZnO alone, ZnO-MTAP conjugates have low toxicity under dark conditions but high phototoxicity in the human ovarian carcinoma cell line NIH:OVCAR-3. The results indicate that ZnO-MTAP conjugates may be useful in photodynamic therapy for deep cancer treatment.

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页数：3

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