Genetics of antiphospholipid syndrome

被引：7

作者：

Atsumi, T

Bertolaccini, ML

Koike, T

机构：

[1] Hokkaido Univ, Sch Med, Dept Med 2, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] St Thomas Hosp, Rayne Inst, Lupus Res Unit, London SE1 7EH, England

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2001年 / 27卷 / 03期

关键词：

D O I：

10.1016/S0889-857X(05)70220-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanisms of thrombosis in antiphospholipid syndrome (APS) are highly heterogeneous and multifactorial, and some genetic factors may be involved in its pathophysiology. The genetic variants of representative antigen, beta (2)-glycoprotein I (beta (2)GPI), have been known, and valine/leucine247 polymorphism is a genetic risk for having antip,GPI antibodies and APS. Congenital beta (2)GPI deficiency did not correlate with thrombophilia, thus its responsible gene (beta (2)GPI-Sapporo) was not a risk for thrombosis. Many other thrombosis-related genetic factors have been investigated in A-PS, but no additional risk for thrombosis has been indicated in patients with antiphospholipid antibodies.

引用

页码：565 / +

页数：9

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