Hypothalamic Control of Lipid Metabolism: Focus on Leptin, Ghrelin and Melanocortins

被引：86

作者：

Dieguez, Carlos ^{[1
,2
]}

Vazquez, Maria J. ^{[1
,2
]}

Romero, Amparo ^{[1
,2
]}

Lopez, Miguel ^{[1
,2
]}

Nogueiras, Ruben ^{[1
,2
]}

机构：

[1] Univ Santiago de Compostela, Sch Med, Dept Physiol, Inst Invest Sanitaria IDIS, ES-15782 Santiago De Compostela, Spain

[2] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela, Spain

来源：

NEUROENDOCRINOLOGY | 2011年 / 94卷 / 01期

关键词：

Hypothalamus; AMP-activated protein kinase; Sympathetic nervous system; NERVOUS-SYSTEM OUTFLOW; HORMONE SECRETAGOGUE RECEPTOR; FOOD-INTAKE; MESSENGER-RNA; OREXIGENIC ACTION; GENE-EXPRESSION; NEUROPEPTIDE-Y; BODY-WEIGHT; MALONYL-COA; ENERGY;

D O I：

10.1159/000328122

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The hypothalamus plays a crucial role in the regulation of food intake and energy expenditure. One of the main regulatory factors within the hypothalamus is AMP-activated protein kinase (AMPK), which is involved in a large number of biological actions including the modulation of energy balance. Leptin and ghrelin-induced changes in hypothalamic AMPK lead to important alterations in hypothalamic fatty acid metabolism. Furthermore, it is well known that the hypothalamus controls peripheral lipid metabolism through the sympathetic nervous system, and those actions are independent of food intake. In this short review, we highlight the main molecular pathways triggered by leptin and ghrelin altering both central and peripheral lipid metabolism and, therefore, controlling feeding behavior and energy expenditure. Copyright (C) 2011 S. Karger AG, Basel

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页码：1 / 11

页数：11

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