H7 avian influenza virus vaccines protect chickens against challenge with antigenically diverse isolates

被引：48

作者：

Abbas, Muhammad Athar ^{[2
,4
]}

Spackman, Erica ^{[1
]}

Fouchier, Ron ^{[3
]}

Smith, Derek ^{[3
,5
,6
]}

Ahmed, Zaheer ^{[2
]}

Siddique, Naila ^{[2
]}

Sarmento, Luciana ^{[1
]}

Naeem, Khalid ^{[2
]}

McKinley, Enid T. ^{[1
]}

Hameed, Abdul ^{[4
]}

Rehmani, Shafqat ^{[7
,8
]}

Swayne, David E. ^{[1
]}

机构：

[1] USDA ARS, SE Poultry Res Lab, Athens, GA 30605 USA

[2] NARC, Natl Reference Lab Poultry Dis, Islamabad 45500, Pakistan

[3] Erasmus MC, Dept Virol, Rotterdam, Netherlands

[4] Quaid I Azam Univ, Dept Microbiol & Biotechnol, Islamabad 45320, Pakistan

[5] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

[6] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[7] Sindh Poultry Vaccine Ctr, Karachi, Pakistan

[8] Univ Vet & Anim Sci Lahore, Lahore, Pakistan

来源：

VACCINE | 2011年 / 29卷 / 43期

关键词：

Antigenic cartography; Avian influenza virus; H7; Poultry; Vaccination; PAKISTAN; POULTRY; HEMAGGLUTININ; PCR;

D O I：

10.1016/j.vaccine.2011.07.064

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

\ Vaccination has been a critical tool in the control of some avian influenza viruses (AIV) and has been used routinely in Pakistan to help control sporadic outbreaks of highly pathogenic (HP) H7 AIV since 1995. During that time, several AIV isolates were utilized as inactivated vaccines with varying degrees of success. In order to evaluate which H7 AIV strains may serve as optimal vaccines for diverse H7 AIVs from Pakistan we conducted vaccination-challenge studies with five H7 vaccines against challenge with two HPAIVs: A/chicken/Murree/NARC-1/1995 H7N3 and A/chicken/Karachi/SPVC-4/2004 H7N3. To further characterize the isolates antigenic cartography was used to visually demonstrate the antigenic relationships among the isolates. All vaccines provided similar protection against mortality, morbidity and shedding of challenge virus from the respiratory tract. However, some minor (not statistically significant) differences were observed and correlated with antibody levels induced by the vaccine prior to challenge. Published by Elsevier Ltd.

引用

页码：7424 / 7429

页数：6

共 17 条

[1] Sequence and phylogenetic analysis of H7N3 avian influenza viruses isolated from poultry in Pakistan 1995-2004 [J].