Clinical trial update: neuroprotection against acute ischaemic stroke

被引:22
作者
Devuyst, G [1 ]
Bogousslavsky, J [1 ]
机构
[1] CHU Vaudois, Dept Neurol, CH-1011 Lausanne, Switzerland
关键词
D O I
10.1097/00019052-199902000-00012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
One of the most recent advances and hopes in stroke therapy concerns neuroprotection, which has recently been investigated in several clinical trials. Furthermore, some new neuroprotective drugs, which are based on newly identified cellular and molecular mechanisms that underlie the development of focal ischaemic injury, will be tested in stroke patients in the future, It must be emphasized, however, that the concept and application of neuroprotection must remain within the frame of the global network and organization of acute stroke care, because neuroprotection at best may become only a link among many other management strategies for acute stroke. Curr Opin Neurology 12:73-79. (C) 1999 Lippincott Williams & Wilkins.
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页码:73 / 79
页数:7
相关论文
共 41 条
[1]   SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF THE N-METHYL-D-ASPARTATE ANTAGONIST DEXTRORPHAN IN PATIENTS WITH ACUTE STROKE [J].
ALBERS, GW ;
ATKINSON, RP ;
KELLEY, RE ;
ROSENBAUM, DM .
STROKE, 1995, 26 (02) :254-258
[2]  
Albers GW, 1995, ANN NY ACAD SCI, V765, P249
[3]   FEVER IN ACUTE STROKE WORSENS PROGNOSIS - A PROSPECTIVE-STUDY [J].
AZZIMONDI, G ;
BASSEIN, L ;
NONINO, F ;
FIORANI, L ;
VIGNATELLI, L ;
RE, G ;
DALESSANDRO, R .
STROKE, 1995, 26 (11) :2040-2043
[4]   Stroke treatment - Promising but still struggling [J].
Caplan, LR .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (16) :1304-1306
[5]   MORTALITY AND MORBIDITY OF ACUTE CEREBRAL INFARCTION RELATED TO TEMPERATURE AND BASAL ANALYTIC PARAMETERS [J].
CASTILLO, J ;
MARTINEZ, F ;
LEIRA, R ;
PRIETO, JM ;
LEMA, M ;
NOYA, M .
CEREBROVASCULAR DISEASES, 1994, 4 (02) :66-71
[6]   A randomized dose-response trial of citicoline in acute ischemic stroke patients [J].
Clark, WM ;
Warach, SJ ;
Pettigrew, LC ;
Gammans, RE ;
Sabounjian, LA .
NEUROLOGY, 1997, 49 (03) :671-678
[7]   Termination of acute stroke studies involving selfotel treatment [J].
Davis, SM ;
Albers, GW ;
Diener, HC ;
Lees, KR ;
Norris, J .
LANCET, 1997, 349 (9044) :32-32
[8]   Treatment of acute ischemic stroke with piracetam [J].
DeDeyn, PP ;
DeReuck, J ;
Deberdt, W ;
Vlietinck, R ;
Orgogozo, JM .
STROKE, 1997, 28 (12) :2347-2352
[9]   Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke [J].
Diener, HC .
CEREBROVASCULAR DISEASES, 1998, 8 (03) :172-181
[10]   Duration of neuroprotective treatment for ischemic stroke [J].
Dyker, AG ;
Lees, KR .
STROKE, 1998, 29 (02) :535-542