Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons

被引:276
作者
Prahlad, Veena [1 ]
Cornelius, Tyler [1 ]
Morimoto, Richard I. [1 ]
机构
[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Rice Inst Biomed Res, Evanston, IL 60208 USA
关键词
D O I
10.1126/science.1156093
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress- inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell- autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell- autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature- dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress- related responses to establish an organismal response to environmental change.
引用
收藏
页码:811 / 814
页数:4
相关论文
共 19 条
[1]   Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients [J].
Clark, Damon A. ;
Gabel, Christopher V. ;
Gabel, Harrison ;
Samuel, Aravinthan D. T. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (23) :6083-6090
[2]   Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity [J].
Cui, Yuxia ;
McBride, Sandra J. ;
Boyd, Windy A. ;
Alper, Scott ;
Freedman, Jonathan H. .
GENOME BIOLOGY, 2007, 8 (06)
[3]  
FAWCETT TW, 1994, J BIOL CHEM, V269, P32272
[4]   THE CONSEQUENCES OF EXPRESSING HSP70 IN DROSOPHILA CELLS AT NORMAL TEMPERATURES [J].
FEDER, JH ;
ROSSI, JM ;
SOLOMON, J ;
SOLOMON, N ;
LINDQUIST, S .
GENES & DEVELOPMENT, 1992, 6 (08) :1402-1413
[5]   Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells [J].
Garcia, Susana M. ;
Casanueva, M. Olivia ;
Silva, M. Catarina ;
Amaral, Margarida D. ;
Morimoto, Richard I. .
GENES & DEVELOPMENT, 2007, 21 (22) :3006-3016
[6]   A PHEROMONE-INDUCED DEVELOPMENTAL SWITCH IN CAENORHABDITIS-ELEGANS - TEMPERATURE-SENSITIVE MUTANTS REVEAL A WILD-TYPE TEMPERATURE-DEPENDENT PROCESS [J].
GOLDEN, JW ;
RIDDLE, DL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (03) :819-823
[7]   The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans [J].
Hajdu-Cronin, YM ;
Chen, WJ ;
Sternberg, PW .
GENETICS, 2004, 168 (04) :1937-1949
[8]   Regulation of aging and age-related disease by DAF-16 and heat-shock factor [J].
Hsu, AL ;
Murphy, CT ;
Kenyon, C .
SCIENCE, 2003, 300 (5622) :1142-1145
[9]  
Hu P. J., 2007, WormBook, V8, P1, DOI [10.1895/wormbook.1.144.1, DOI 10.1895/WORMBOOK.1.144.1]
[10]   Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans [J].
Inada, H ;
Ito, H ;
Satterlee, J ;
Sengupta, P ;
Matsumoto, K ;
Mori, I .
GENETICS, 2006, 172 (04) :2239-2252