The role of iron in the immune response to bacterial infection

被引：148

作者：

Cherayil, Bobby J. ^{[1
,2
]}

机构：

[1] MassGen Hosp Children, Mucosal Immunol Lab, MGH E, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

IMMUNOLOGIC RESEARCH | 2011年 / 50卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Iron metabolism; Infection; Inflammation; Macrophage; Siderophore; HEREDITARY HEMOCHROMATOSIS PROTEIN; HEPCIDIN EXPRESSION; MYCOBACTERIUM-TUBERCULOSIS; MOLECULAR-MECHANISM; HFE-DEFICIENT; HOST-DEFENSE; IN-VIVO; FERROPORTIN; HOMEOSTASIS; GROWTH;

D O I：

10.1007/s12026-010-8199-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

My laboratory has been interested for some time in the influence of iron, a nutrient that is essential for both microbial pathogens and their mammalian hosts, on the course of infectious disease. Our studies indicate that alterations in the expression of host molecules that sequester or transport iron can have direct effects on pathogen growth and can also have an impact on the ability to mount normal immune responses. We have elucidated the mechanistic basis for some of these observations, and have started to apply our findings in strategies to control abnormalities of inflammation and iron metabolism. I will review here what we have learned about the interactions between iron and immunity and discuss the implications of the information that we have acquired.

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页码：1 / 9

页数：9

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