Parental occupational exposure to pesticides and childhood germ-cell tumors

被引:21
作者
Chen, Z
Stewart, PA
Davies, S
Giller, R
Krailo, M
Davis, M
Robison, L
Shu, XO
机构
[1] Vanderbilt Univ, Ctr Hlth Serv Res, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA
[3] NCI, Div Canc Epidemiol & Genet, Occupat & Environm Epidemiol Branch, Bethesda, MD 20892 USA
[4] Cincinnati Childrens Hosp & Med Ctr, Cincinnati, OH USA
[5] Childrens Hosp, Denver, CO 80218 USA
[6] Univ So Calif, Keck Sch Med, Los Angeles, CA 90089 USA
[7] James Whitcomb Riley Hosp Children, Div Pediat Pathol, Indianapolis, IN 46202 USA
[8] Univ Minnesota, Dept Pediat, Div Epidemiol & Clin Res, Sch Med, Minneapolis, MN 55455 USA
关键词
case-control studies; child; germinoma; occupational exposure; pesticides;
D O I
10.1093/aje/kwi294
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
In a recently completed US case-control study (Children's Oncology Group, 1993-2001) with 253 cases and 394 controls, the authors investigated the association between parental occupational exposure to pesticides and risk of childhood germ-cell tumors. Information on occupational pesticide exposure was collected using job-specific module questionnaires and assessed by an experienced industrial hygienist. Odds ratios for childhood germ-cell tumors associated with maternal exposures before pregnancy, during pregnancy, and after the birth of the index child were 1.0 (95% confidence interval (CI): 0.8, 1.4), 1.1 (95% CI: 0.7, 1.6), and 1.3 (95% CI: 0.9, 1.8), respectively. Paternal exposures before pregnancy, during pregnancy, and after the birth of the index child were not related to germ-cell tumors (odds ratios (ORs) were 0.9 (95% CI: 0.7, 1.2), 0.8 (95% CI: 0.5, 1.2), and 0.8 (95% CI: 0.5, 1.3), respectively). When both parents had ever been occupationally exposed to pesticides before the index pregnancy, the odds ratio was 0.8 (95% CI: 0.4, 1.3). Subgroup analyses showed a positive association between maternal exposure to herbicides during the postnatal period and risk of germ-cell tumors in girls (OR = 2.3, 95% CI: 1.0, 5.2) and an inverse association between paternal exposure to pesticides during the index pregnancy and germ-cell tumors in boys (OR = 0.2, 95% CI: 0.1, 1.0). This study did not provide strong evidence supporting a relation between parental pesticide exposure in the workplace and risk of germ-cell tumors among offspring.
引用
收藏
页码:858 / 867
页数:10
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