Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production

被引：284

作者：

Starnes, T

Robertson, MJ

Sledge, G

Kelich, S

Nakshatri, H

Broxmeyer, HE

Hromas, R

机构：

[1] Indiana Univ, Med Ctr, Walther Oncol Ctr, Dept Med & Biochem, Indianapolis, IN 46202 USA

[2] Indiana Univ, Med Ctr, Walther Oncol Ctr, Dept Surg, Indianapolis, IN 46202 USA

[3] Indiana Univ, Med Ctr, Walther Oncol Ctr, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA

[4] Walther Canc Inst, Indianapolis, IN 46206 USA

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 167卷 / 08期

关键词：

D O I：

10.4049/jimmunol.167.8.4137

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel secreted cytokine, termed IL-17F, was cloned using nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was expressed only in activated CD4(+) T cells and activated monocytes. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1.

引用

页码：4137 / 4140

页数：4

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