Functional Characterization of Stem Cell Activity in the Mouse Mammary Gland

被引：17

作者：

Bruno, Robert D. ^{[1
]}

Smith, Gilbert H. ^{[1
]}

机构：

[1] NCI, Mammary Biol & Tumorigenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

STEM CELL REVIEWS AND REPORTS | 2011年 / 7卷 / 02期

关键词：

Stem cells; Mammary gland; Niche; Label-retaining cells; Asymmetric DNA segregation; Parity identified mammary epithelial cells; Lobule progenitor; Ductal progenitor; LABEL-RETAINING CELLS; TEMPLATE DNA STRANDS; EPITHELIAL-CELLS; IN-VIVO; TGF-BETA-1; EXPRESSION; SELECTIVE SEGREGATION; DIFFERENTIATION; RECEPTOR; CANCER; MICROENVIRONMENT;

D O I：

10.1007/s12015-010-9191-9

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Any portion of the mouse mammary gland is capable of recapitulating a clonally derived complete and functional mammary tree upon transplantation into an epithelial divested mammary fat-pad of a recipient host. As such, it is an ideal model tissue for the study somatic stem cell function. This review will outline what is known regarding the function of stem/progenitor cells in the mouse mammary gland, including how progenitor populations can be functionally defined, the evidence for and potential role of selective DNA strand segregation, and the role of the niche in maintaining and controlling stem cell function.

引用

页码：238 / 247

页数：10

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