Enteropathogenic Escherichia coli virulence genes encoding secreted signalling proteins are essential for modulation of Caco-2 cell electrolyte transport

被引：29

作者：

Collington, GK

Booth, IW

Donnenberg, MS

Kaper, JB

Knutton, S

机构：

[1] Univ Birmingham, Inst Child Hlth, Birmingham B4 6NH, W Midlands, England

[2] Univ Maryland, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Med, Dept Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 12期

关键词：

D O I：

10.1128/IAI.66.12.6049-6053.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathophysiology of enteropathogenic Escherichia coli (EPEC) diarrhea remains uncertain. In vitro, EPEC stimulates a rapid increase in short-circuit current (I-sc) across Caco-2 cell monolayers coincident with intimate attaching and effacing (A/E) bacterial adhesion. This study has examined the roles of specific EPEC virulence proteins in this I-sc response. EPEC genes encoding EspA, EspB, and EspD, essential for signal transduction in host cells and A/E activity, were also required for modulation of Caco-2 electrolyte transport.

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收藏

页码：6049 / 6053

页数：5

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