The effect of sleep deprivation on BOLD activity elicited by a divided attention task

被引:27
作者
Jackson, Melinda L. [2 ,3 ]
Hughes, Matthew E. [4 ]
Croft, Rodney J. [4 ,5 ]
Howard, Mark E. [2 ,6 ]
Crewther, David [4 ]
Kennedy, Gerard A. [2 ,7 ]
Owens, Katherine [4 ]
Pierce, Rob J. [2 ,6 ]
O'Donoghue, Fergal J. [2 ,6 ,8 ]
Johnston, Patrick [1 ]
机构
[1] Univ York, Dept Psychol, Heslington York YO10 5DD, England
[2] Austin Hlth, Inst Breathing & Sleep, Melbourne, Vic, Australia
[3] Washington State Univ, Sleep & Performance Res Ctr, Spokane, WA USA
[4] Swinburne Univ Technol, Brain Sci Inst, Melbourne, Vic, Australia
[5] Univ Wollongong, Wollongong, NSW, Australia
[6] Univ Melbourne, Melbourne, Vic, Australia
[7] Victoria Univ, Sch Social Sci & Psychol, Melbourne, Vic 8001, Australia
[8] Austin Hlth, Brain Res Inst, Melbourne, Vic, Australia
关键词
Sleep deprivation; Neuroimaging; Prefrontal cortex; Divided attention; Selective attention; POSITRON-EMISSION-TOMOGRAPHY; DAYTIME SLEEPINESS; LONDON PERFORMANCE; PREFRONTAL CORTEX; WORKING-MEMORY; BRAIN; ALERTNESS; INTEGRATION; COGNITION; DURATION;
D O I
10.1007/s11682-011-9115-6
中图分类号
R445 [影像诊断学];
学科分类号
100231 [临床病理学];
摘要
Sleep loss, widespread in today's society and associated with a number of clinical conditions, has a detrimental effect on a variety of cognitive domains including attention. This study examined the sequelae of sleep deprivation upon BOLD fMRI activation during divided attention. Twelve healthy males completed two randomized sessions; one after 27 h of sleep deprivation and one after a normal night of sleep. During each session, BOLD fMRI was measured while subjects completed a cross-modal divided attention task (visual and auditory). After normal sleep, increased BOLD activation was observed bilaterally in the superior frontal gyrus and the inferior parietal lobe during divided attention performance. Subjects reported feeling significantly more sleepy in the sleep deprivation session, and there was a trend towards poorer divided attention task performance. Sleep deprivation led to a down regulation of activation in the left superior frontal gyrus, possibly reflecting an attenuation of top-down control mechanisms on the attentional system. These findings have implications for understanding the neural correlates of divided attention and the neurofunctional changes that occur in individuals who are sleep deprived.
引用
收藏
页码:97 / 108
页数:12
相关论文
共 52 条
[1]
Predicting duration of sleep from the three process model of regulation of alertness [J].
Akerstedt, T ;
Folkard, S .
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1996, 53 (02) :136-141
[2]
[Anonymous], 1992, EDITS MANUAL PROFILE
[3]
[Anonymous], 1999, MODELS WORKING MEMOR, DOI [10.1017/CBO9781139174909.006, DOI 10.1017/CBO9781139174909.006]
[4]
Cognitive, sensory and physical factors enabling driving safety in older adults [J].
Anstey, KJ ;
Wood, J ;
Lord, S ;
Walker, JG .
CLINICAL PSYCHOLOGY REVIEW, 2005, 25 (01) :45-65
[5]
American time use survey: Sleep time and its relationship to waking activities [J].
Basner, Mathias ;
Fomberstein, Kenneth M. ;
Razavi, Farid M. ;
Banks, Siobhan ;
William, Jeffrey H. ;
Rosa, Roger R. ;
Dinges, David F. .
SLEEP, 2007, 30 (09) :1085-1095
[6]
Boivin DB, 2000, J PSYCHIATR NEUROSCI, V25, P446
[7]
Lapsing during sleep deprivation is associated with distributed changes in brain activation [J].
Chee, Michael W. L. ;
Tan, Jiat Chow ;
Zheng, Hui ;
Parimal, Sarayu ;
Weissman, Daniel H. ;
Zagorodnov, Vitali ;
Dinges, David F. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (21) :5519-5528
[8]
Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation [J].
Chee, Michael W. L. ;
Chuah, Y. M. Lisa .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (22) :9487-9492
[9]
Dissociation of cortical regions modulated by both working memory load and sleep deprivation and by sleep deprivation alone [J].
Choo, WC ;
Lee, WW ;
Venkatraman, V ;
Sheu, FS ;
Chee, MWL .
NEUROIMAGE, 2005, 25 (02) :579-587
[10]
CORBETTA M, 1991, J NEUROSCI, V11, P2383