Screening the SP011 and EIF5A2 genes in a population of infertile men

被引：25

作者：

Christensen, GL

Ivanov, IP

Atkins, JF

Mielnik, A

Schlegel, PN

Carrell, DT

机构：

[1] Univ Utah, Androl & IVF Labs, Sch Med, Salt Lake City, UT 84108 USA

[2] Univ Utah, Dept Physiol, Sch Med, Salt Lake City, UT 84108 USA

[3] Univ Utah, Dept Human Genet, Sch Med, Salt Lake City, UT 84108 USA

[4] Natl Univ Ireland Univ Coll Cork, Biosci Inst, Cork, Ireland

[5] Cornell Univ, Weill Med Coll, New York, NY 10021 USA

来源：

FERTILITY AND STERILITY | 2005年 / 84卷 / 03期

关键词：

D O I：

10.1016/j.fertnstert.2005.03.053

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Populations of infertile and fertile men were screened for mutations in SPO11 and EIF5A2, two infertility candidate genes. Three heterozygous amino acid changes that might contribute to infertility were identified in the infertile group.

引用

页码：758 / 760

页数：3

共 19 条

[1] Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11 [J].

Baudat, F ;

Manova, K ;

Yuen, JP ;

Jasin, M ;

Keeney, S .

MOLECULAR CELL, 2000, 6 (05) :989-998

[2] The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis [J].

Caraglia, M ;

Marra, M ;

Giuberti, G ;

D'Alessandro, AM ;

Budillon, A ;

del Prete, S ;

Lentini, A ;

Beninati, S ;

Abbruzzese, A .

AMINO ACIDS, 2001, 20 (02) :91-104

[3]

Christensen GL, 2002, ASIAN J ANDROL, V4, P213

[4] Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation [J].

Diaz, RL ;

Alcid, AD ;

Berger, JM ;

Keeney, S .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (04) :1106-1115

[5] Impact of genetic engineering on the understanding of spermatogenesis [J].

Escalier, D .

HUMAN REPRODUCTION UPDATE, 2001, 7 (02) :191-210

[6] Absence of mutations in the PCI gene in subfertile men [J].

Gianotten, J ;

Schimmel, AWM ;

van der Veen, F ;

Lombardi, MP ;

Meijers, JCM .

MOLECULAR HUMAN REPRODUCTION, 2004, 10 (11) :807-813

[7] CHARACTERIZATION OF A TRANSGENIC MOUSE LINE OVER-EXPRESSING THE HUMAN ORNITHINE DECARBOXYLASE GENE [J].

HALMEKYTO, M ;

ALHONEN, L ;

WAHLFORS, J ;

SINERVIRTA, R ;

ELORANTA, T ;

JANNE, J .

BIOCHEMICAL JOURNAL, 1991, 278 :895-898

[8] Genetic basis of male fertility [J].

Hargreave, TB .

BRITISH MEDICAL BULLETIN, 2000, 56 (03) :650-671

[9] Cell cycle arrest in archaea by the hypusination inhibitor N1-guanyl-1,7-diaminoheptane [J].

Jansson, BPM ;

Malandrin, L ;

Johansson, HE .

JOURNAL OF BACTERIOLOGY, 2000, 182 (04) :1158-1161

[10] Human EIF5A2 an chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression [J].

Jenkins, ZA ;

Hååg, PG ;

Johansson, HE .

GENOMICS, 2001, 71 (01) :101-109

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