Spirostanol Saponins Derivated from the Seeds of Trigonella foenum-graecum by β-Glucosidase Hydrolysis and Their Inhibitory Effects on Rat Platelet Aggregation

被引：18

作者：

Pang, Xu ^{[1
]}

Cong, Yue ^{[2
]}

Yu, He-Shui ^{[1
]}

Kang, Li-Ping ^{[1
]}

Feng, Bing ^{[1
]}

Han, Bing-Xing ^{[2
]}

Zhao, Yang ^{[1
]}

Xiong, Cheng-Qi ^{[1
]}

Tan, Da-Wei ^{[1
]}

Song, Wei ^{[3
]}

Liu, Bin ^{[3
]}

Cong, Yu-Wen ^{[2
]}

Ma, Bai-Ping ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, Dept Biotechnol, Beijing 100850, Peoples R China

[2] Beijing Inst Radiat Med, Dept Pathophysiol, Beijing 100850, Peoples R China

[3] Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 03期

关键词：

Trigonella foenum-graecum; Leguminosae; spirostanol saponins; enzymatic hydrolysis; inhibitory platelet; aggregation activity; MEDICINAL FOODSTUFFS; FUROSTANOL SAPONINS; PLANT SAPONINS; FENUGREEK SEED; STEROIDAL SAPONINS; NMR-SPECTROSCOPY; GLYCOSIDES;

D O I：

10.1055/s-0031-1280373

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Nine spirostanol saponins (1-9) and seven mixtures of 25R and 25S spirostanol saponin isomers (10-16) were obtained from the seeds of Trigonella foenum-graecum after enzymatic hydrolysis of the furostanol saponin fraction by beta-glucosidase. Their structures were determined by NMR and MS spectroscopy. Among them, 1-4, 6, 8, and 9 were new compounds and five, 11b, 12a, 13b, 14a, and 14b, were new structures observed from seven mixtures. In addition, the inhibitory effects of all saponins on rat platelet aggregation were evaluated.

引用

页码：276 / 285

页数：10

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