Increased ΔN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived ΔN′-p73 transcript

被引:42
作者
Pützer, B [1 ]
Tuve, S
Tannapfel, A
Stiewe, T
机构
[1] Univ Essen Gesamthsch, Inst Mol Biol, Ctr Canc Res & Canc Therapy, Essen, Germany
[2] Univ Wurzburg, Rudolf Virchow Ctr Expt Biomed, Wurzburg, Germany
关键词
D O I
10.1038/sj.cdd.4401205
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:612 / 614
页数:3
相关论文
共 17 条
[1]   Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients [J].
Casciano, I ;
Mazzocco, K ;
Boni, L ;
Pagnan, G ;
Banelli, B ;
Allemanni, G ;
Ponzoni, M ;
Tonini, GP ;
Romani, M .
CELL DEATH AND DIFFERENTIATION, 2002, 9 (03) :246-251
[2]   Two new p73 splice variants, γ and δ, with different transcriptional activity [J].
De Laurenzi, V ;
Costanzo, A ;
Barcaroli, D ;
Terrinoni, A ;
Falco, M ;
Annicchiarico-Petruzzeli, M ;
Levrero, M ;
Melino, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (09) :1763-1768
[3]   Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53 [J].
Grob, TJ ;
Novak, U ;
Maisse, C ;
Barcaroli, D ;
Lüthi, AU ;
Pirnia, F ;
Hügli, B ;
Graber, HU ;
De Laurenzi, V ;
Fey, MF ;
Melino, G ;
Tobler, A .
CELL DEATH AND DIFFERENTIATION, 2001, 8 (12) :1213-1223
[4]   Role for the p53 homologue p73 in E2F-1-induced apoptosis [J].
Irwin, M ;
Marin, MC ;
Phillips, AC ;
Seelan, RS ;
Smith, DI ;
Liu, WG ;
Flores, ER ;
Tsai, KY ;
Jacks, T ;
Vousden, KH ;
Kaelin, WG .
NATURE, 2000, 407 (6804) :645-648
[5]  
Ishimoto O, 2002, CANCER RES, V62, P636
[6]   Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers [J].
Kaghad, M ;
Bonnet, H ;
Yang, A ;
Creancier, L ;
Biscan, JC ;
Valent, A ;
Minty, A ;
Chalon, P ;
Lelias, JM ;
Dumont, X ;
Ferrara, P ;
McKeon, F ;
Caput, D .
CELL, 1997, 90 (04) :809-819
[7]   p53 induces the expression of its antagonist p73ΔN, establishing an autoregulatory feedback loop [J].
Kartasheva, NN ;
Contente, A ;
Lenz-Stöppler, C ;
Roth, J ;
Dobbelstein, M .
ONCOGENE, 2002, 21 (31) :4715-4727
[8]   p73: Friend or foe in tumorigenesis [J].
Melino, G ;
De Laurenzi, V ;
Vousden, KH .
NATURE REVIEWS CANCER, 2002, 2 (08) :605-615
[9]   Autoinhibitory regulation of p73 by ΔNp73 to modulate cell survival and death through a p73-specific target element within the ΔNp73 promoter [J].
Nakagawa, T ;
Takahashi, M ;
Ozaki, T ;
Watanabe, K ;
Todo, S ;
Mizuguchi, H ;
Hayakawa, T ;
Nakagawara, A .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (08) :2575-2585
[10]   An anti-apoptotic role for the p53 family member, p73, during developmental neuron death [J].
Pozniak, CD ;
Radinovic, S ;
Yang, A ;
McKeon, F ;
Kaplan, DR ;
Miller, FD .
SCIENCE, 2000, 289 (5477) :304-306