Human CD38: a (r)evolutionary story of enzymes and receptors

被引：242

作者：

Deaglio, S

Mehta, K

Malavasi, F

机构：

[1] Univ Turin, Sch Med, Dept Biol Genet & Biochem, Cell Biol Lab, I-10126 Turin, Italy

[2] Univ Texas, MD Anderson Canc Ctr, Dept Bioimmunotherapy, Houston, TX 77030 USA

[3] Univ Ancona, Sch Med, Inst Biol & Genet, Ancona, Italy

来源：

LEUKEMIA RESEARCH | 2001年 / 25卷 / 01期

关键词：

CD38; CD157; ectoenzymes; receptors; signaling pathway; B-CLL; APL; AML;

D O I：

10.1016/S0145-2126(00)00093-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human CD38 is the mammalian prototype of a family of proteins which share structural similarities and an ectoenzymatic activity involved in the production of calcium mobilizing compounds. Besides the enzymatic activity, the molecule performs as a receptor, ruling adhesion and signaling in leukocytes. These functions are exerted through the interaction with surface ligands, one of which was identified as CD31. Recently, CD38 has gained attention as a prognostic marker and a pathogenetic agent in leukemias and in other diseases. Together these insights have produced a model of an as yet unique family of molecules, which act independently as receptors and enzymes. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1 / 12

页数：12

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