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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

被引：896
作者：
Parkes, Miles
Barrett, Jeffrey C.
Prescott, Natalie J.
Tremelling, Mark
Anderson, Carl A.
Fisher, Sheila A.
Roberts, Roland G.
Nimmo, Elaine R.
Cummings, Fraser R.
Soars, Dianne
Drummond, Hazel
Lees, Charlie W.
Khawaja, Saud A.
Bagnall, Richard
Burke, Denis A.
Todhunter, Catherine E.
Ahmad, Tariq
Onnie, Clive M.
McArdle, Wendy
Strachan, David
Bethel, Graeme
Bryan, Claire
Lewis, Cathryn M.
Deloukas, Panos
Forbes, Alastair
Sanderson, Jeremy
Jewell, Derek P.
Satsangi, Jack
Mansfield, John C.
Cardon, Lon
Mathew, Christopher G.
机构：
[1] Addenbrookes Hosp, Inflammatory Bowel Dis Res Grp, Cambridge CB2 2QQ, England
[2] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
[3] Kings Coll London, Guys Hosp, Sch Med, Dept Med & Mol Genet, London SE1 9RT, England
[4] Univ Edinburgh, Western Gen Hosp, Sch Mol & Clin Med, Div Med Sci,Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[5] Univ Oxford, Radcliffe Infirm, Gastroenterol Unit, Oxford OX2 6HE, England
[6] Univ Newcastle Upon Tyne, Royal Victoria Infirm, Dept Gastroenterol & Hepatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
[7] Univ Bristol, ALSPAC, Bristol BS8 1TQ, Avon, England
[8] St Georges Univ London, Div Community Hlth Serv, London SW17 0RE, England
[9] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
[10] UCL, Hosp Trust, Inst Digest Dis, London NW1 2BU, England
[11] Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, England
来源：
NATURE GENETICS | 2007年 / 39卷 / 07期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
D O I：
10.1038/ng2061
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
引用
收藏
页码：830 / 832
页数：3
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