Antimalarial activity of 2,4,6-trisubstituted pyrimidines

被引：37

作者：

Agarwal, A

Srivastava, K

Puri, SK

Chauhan, PMS ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 07期

关键词：

dihydrofolate reductase; antimalarial; pyrimidine;

D O I：

10.1016/j.bmcl.2005.02.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of 2,4,6-trisubstituted pyrimidines (3a-o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5-2 mu g/mL. These compounds are in vitro several folds more active than pyrimethamine. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：1881 / 1883

页数：3

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