Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14

被引：5

作者：

Aventín, A

Nomdedéu, J

Briones, J

Espinosa, I

Bordes, R

Sierra, J

机构：

[1] Hosp Sant Pau, Dept Haematol, Barcelona 08025, Spain

[2] Hosp Sant Pau, Dept Pathol, Barcelona 08025, Spain

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2003年 / 56卷 / 10期

关键词：

D O I：

10.1136/jcp.56.10.798

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The t(11;14)(q13;q32) translocation is considered to be the cytogenetic hallmark of mantle cell lymphoma. This report describes a case of leukaemic mantle cell lymphoma in which conventional cytogenetics on stimulated peripheral blood cells showed a 46,XY, t(1;12)(p21;q23)/ 46,XY karyotype. Fluorescence in situ hybridisation analysis using a dual colour immunoglobulin heavy chain (IgH)/CCND1 probe showed a fusion hybridisation signal on one normal chromosome 14, indicating that an insertion of the CCND1 gene into the 14q32/IgH locus had taken place. Overexpression of the cyclin D1 protein was demonstrated on bone marrow trephine by immunohistochemical staining.

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收藏

页码：798 / 800

页数：3

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