Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum

被引：50

作者：

Harding, WW ^{[1
]}

Tidgewell, K

Schmidt, M

Shah, K

Dersch, CM

Snyder, J

Parrish, D

Deschamps, JR

Rothman, RB

Prisinzano, TE

机构：

[1] Univ Iowa, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

[2] NIDA, IRP, DHHS,Lab Struct Matter,Code 6030, Clin Psychopharmacol Sect,NIH, Baltimore, MD 21224 USA

[3] Naval Res Lab, Washington, DC USA

[4] Univ Iowa, High Field NMR Facil, Iowa City, IA 52242 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 14期

关键词：

D O I：

10.1021/ol0510522

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including H-1 and C-13 NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.

引用

页码：3017 / 3020

页数：4

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