Brain renin-angiotensin system - Lessons from functional genomics

被引：22

作者：

Baltatu, O ^{[1
]}

Bader, M ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, DE-13125 Berlin, Germany

来源：

NEUROENDOCRINOLOGY | 2003年 / 78卷 / 05期

关键词：

angiotensins; brain renin-angiotensin system; molecular neuroendocrinology; electrolyte homeostasis; blood pressure; hypertension;

D O I：

10.1159/000074446

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The existence of a brain renin- angiotensin system ( RAS) was postulated 30 years ago. Since then our knowledge on the biology of the brain RAS has advanced considerably. The brain RAS has been found to be involved in the modulation of cardiovascular and fluid- electrolyte homeostasis, generally complementing the classical roles of the endocrine RAS. The RAS has additionally been implicated in other brain- specific functions, such as memory, cognition and stress. During the last years, the development of transgenic technologies allowed to get further insight into the functionality and relevance of the brain RAS. This paper is attempting to summarize our recent experience from transgenic animals. Copyright (C) 2003 S. Karger AG, Basel.

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收藏

页码：253 / 259

页数：7

相关论文

共 66 条

[1]

Aguilera G, 1996, ADV EXP MED BIOL, V396, P105

[2] Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin-regulated aminopeptidase [J].

Albiston, AL ;

McDowall, SG ;

Matsacos, D ;

Sim, P ;

Clune, E ;

Mustafa, T ;

Lee, J ;

Mendelsohn, FAO ;

Simpson, RJ ;

Connolly, LM ;

Chai, SY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (52) :48623-48626

[3] Angiotensin II receptors in the human brain [J].

Allen, AM ;

MacGregor, DP ;

McKinley, MJ ;

Mendelsohn, FAO .

REGULATORY PEPTIDES, 1999, 79 (01) :1-7

[4] Angiotensin peptides and baroreflex control of sympathetic outflow: Pathways and mechanisms of the medulla oblongata [J].

Averill, DB ;

Diz, DI .

BRAIN RESEARCH BULLETIN, 2000, 51 (02) :119-128

[5] Tissue renin-angiotensin systems:: new insights from experimental animal models in hypertension research [J].

Bader, J ;

Peters, J ;

Baltatu, O ;

Müller, DN ;

Luft, FC ;

Ganten, D .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2001, 79 (2-3) :76-102

[6] Clock genes in mammalian peripheral tissues [J].

Balsalobre, A .

CELL AND TISSUE RESEARCH, 2002, 309 (01) :193-199

[7] Locally synthesized angiotensin modulates pineal melatonin generation [J].

Baltatu, O ;

Afeche, SC ;

dos Santos, SHJ ;

Campos, LA ;

Barbosa, R ;

Michelini, LC ;

Bader, M ;

Cipolla-Neto, J .

JOURNAL OF NEUROCHEMISTRY, 2002, 80 (02) :328-334

[8] High levels of human chymase expression in the pineal and pituitary glands [J].

Baltatu, O ;

Nishimura, H ;

Hoffmann, S ;

Stoltenburg, G ;

Haulica, ID ;

Lippoldt, A ;

Ganten, D ;

Urata, H .

BRAIN RESEARCH, 1997, 752 (1-2) :269-278

[9] Alterations in blood pressure and heart rate variability in transgenic rats with low brain angiotensinogen [J].

Baltatu, O ;

Janssen, BJ ;

Bricca, G ;

Plehm, R ;

Monti, J ;

Ganten, D ;

Bader, M .

HYPERTENSION, 2001, 37 (02) :408-413

[10] Alterations of the renin-angiotensin system at the RVLM of transgenic rats with low brain angiotensinogen [J].

Baltatu, O ;

Fontes, MAP ;

Campagnole-Santos, MJ ;

Caligiorni, S ;

Ganten, D ;

Santos, RAS ;

Bader, M .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (02) :R428-R433

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