A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus

被引：287

作者：

Wolfe-Simon, Felisa ^{[1
,2
]}

Blum, Jodi Switzer ^{[2
]}

Kulp, Thomas R. ^{[2
]}

Gordon, Gwyneth W. ^{[3
]}

Hoeft, Shelley E. ^{[2
]}

Pett-Ridge, Jennifer ^{[4
]}

Stolz, John F. ^{[5
]}

Webb, Samuel M. ^{[6
]}

Weber, Peter K. ^{[4
]}

Davies, Paul C. W. ^{[1
,7
]}

Anbar, Ariel D. ^{[1
,3
,8
]}

Oremland, Ronald S. ^{[2
]}

机构：

[1] NASA, Astrobiol Inst, Washington, DC 20546 USA

[2] US Geol Survey, Menlo Pk, CA 94025 USA

[3] Arizona State Univ, Sch Earth & Space Explorat, Tempe, AZ 85287 USA

[4] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA

[5] Duquesne Univ, Dept Biol Sci, Pittsburgh, PA 15282 USA

[6] Stanford Synchrotron Radiat Lightsource, Menlo Pk, CA 94025 USA

[7] Arizona State Univ, BEYOND Ctr Fundamental Concepts Sci, Tempe, AZ 85287 USA

[8] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

来源：

SCIENCE | 2011年 / 332卷 / 6034期

基金：

美国国家卫生研究院;

关键词：

MARINE;

D O I：

10.1126/science.1197258

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Life is mostly composed of the elements carbon, hydrogen, nitrogen, oxygen, sulfur, and phosphorus. Although these six elements make up nucleic acids, proteins, and lipids and thus the bulk of living matter, it is theoretically possible that some other elements in the periodic table could serve the same functions. Here, we describe a bacterium, strain GFAJ-1 of the Halomonadaceae, isolated from Mono Lake, California, that is able to substitute arsenic for phosphorus to sustain its growth. Our data show evidence for arsenate in macromolecules that normally contain phosphate, most notably nucleic acids and proteins. Exchange of one of the major bio-elements may have profound evolutionary and geochemical importance.

引用

页码：1163 / 1166

页数：4

共 18 条

[1]

[Anonymous], 2009, J AM CHEM SOC, DOI DOI 10.1021/JA906434C

[2] KINETICS OF THE HYDROLYSIS OF ARSENATE(V) TRIESTERS [J].

BAER, CD ;

EDWARDS, JO ;

RIEGER, PH .

INORGANIC CHEMISTRY, 1981, 20 (03) :905-907

[3]

Berg J.M., 2007, Biochemistry, V6th

[4] Bacillus arsenicoselenatis, sp nov, and Bacillus selenitireducens, sp nov:: two haloalkaliphiles from Mono Lake, California that respire oxyanions of selenium and arsenic [J].

Blum, JS ;

Bindi, AB ;

Buzzelli, J ;

Stolz, JF ;

Oremland, RS .

ARCHIVES OF MICROBIOLOGY, 1998, 171 (01) :19-30

[5] Molybdenum and tungsten in biology [J].

Hille, R .

TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (07) :360-367

[6] ANISOTROPIC THERMAL-PARAMETER REFINEMENT OF THE DNA DODECAMER CGCGAATTCGCG BY THE SEGMENTED RIGID-BODY METHOD [J].

HOLBROOK, SR ;

DICKERSON, RE ;

KIM, SH .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1985, 41 (AUG) :255-262

[7]

Jameson G. B., 2007, BIOL INORGANIC CHEM, P354

[8] A biological function for cadmium in marine diatoms [J].

Lane, TW ;

Morel, FMM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4627-4631

[9] Are bacteria more like plants or animals?: Growth rate and resource dependence of bacterial C : N : P stoichiometry [J].

Makino, W ;

Cotner, JB ;

Sterner, RW ;

Elser, JJ .

FUNCTIONAL ECOLOGY, 2003, 17 (01) :121-130

[10] INTRACELLULAR TURNOVER OF PROTEIN AND NUCLEIC ACIDS AND ITS ROLE IN BIOCHEMICAL DIFFERENTIATION [J].

MANDELSTAM, J .

BACTERIOLOGICAL REVIEWS, 1960, 24 (03) :289-308

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