Patients with early stage chronic lymphocytic leukemia: new risk stratification based on molecular profiling

被引：5

作者：

Antic, Darko ^{[1
]}

Mihaljevic, Biljana ^{[1
,2
]}

Cokic, Vladan ^{[3
]}

Fekete, Marija Dencic ^{[1
]}

Djurasevic, Teodora Karan ^{[4
]}

Pavlovic, Sonja ^{[4
]}

Milic, Natasa ^{[2
]}

Elezovic, Ivo ^{[1
,2
]}

机构：

[1] Clin Ctr Serbia, Clin Hematol, Belgrade 11000, Serbia

[2] Univ Belgrade, Fac Med, Belgrade 11001, Serbia

[3] Inst Med Res, Belgrade, Serbia

[4] Inst Mol Genet & Genet Engn, Belgrade 11001, Serbia

来源：

LEUKEMIA & LYMPHOMA | 2011年 / 52卷 / 07期

关键词：

Lymphoma and Hodgkin disease; molecular genetics; prognostication; PROGNOSTIC INDEX; EXPRESSION;

D O I：

10.3109/10428194.2011.578311

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated molecular and biological parameters reflecting the biology of chronic lymphocytic leukemia (CLL) that may help us to predict the time to first treatment (TTT). A group of 33 patients with newly diagnosed CLL (Binet stage A) were analyzed. We developed a new scoring system based on the serum levels of beta(2)-microglobulin (beta M-2) and vascular endothelial growth factor (VEGF) and the expression of lipoprotein lipase (LPL). Patients with a score of 0 had a TTT of 58.4 months, while patients with a score of 3 (increased levels of beta M-2, LPL, and VEGF) had a significantly shorter TTT of only 10.6 months (p < 0.0001).

引用

页码：1394 / 1397

页数：4

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