Synthesis and antiviral evaluation of C-4-hydrazide derivatives of 2′,3′-dideoxycytidine

被引：3

作者：

Boudou-Vivet, V ^{[1
]}

Mathé, C ^{[1
]}

Gosselin, G ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, Lab Chim Organ Biomol Synth, UMR 5625, F-34095 Montpellier 5, France

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期

关键词：

D O I：

10.1081/NCN-100002484

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Syntheses of three hitherto unknown derivatives of 2',3'-dideoxycytidine, namely C-4-(salicylic hydrazide)-ddC, C-4-(N-butyloxycarbonyl-isoleucine hydrazide)-ddC and its N-unprotected chlorhydrate salt have been carried out. These compounds do not induce inhibition of HIV-1 replication in cell culture experiments. Nevertheless, the modifications on the base moiety increased in all cases the lipophilicity of the parent molecule with an acceptable water solubility compared to ddC.

引用

页码：1029 / 1032

页数：4

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