Signaling in muscle atrophy and hypertrophy

被引：609

作者：

Sandri, Marco ^{[1
,2
]}

机构：

[1] Univ Padua, Dept Biomed Sci, Dulbecco Telethon Inst, Padua, Italy

[2] Venetian Inst Mol Med, Padua, Italy

来源：

PHYSIOLOGY | 2008年 / 23卷 / 03期

关键词：

D O I：

10.1152/physiol.00041.2007

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Muscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which, depending on the condition, can promote muscle growth or loss. Protein synthesis and protein degradation are coordinately regulated by pathways that are influenced by mechanical stress, physical activity, availability of nutrients, and growth factors. Understanding the signaling that regulates muscle mass may provide potential therapeutic targets for the prevention and treatment of muscle wasting in metabolic and neuromuscular diseases.

引用

页码：160 / 170

页数：11

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