Psychiatric genetics: The brains of the family

被引：33

作者：

Abbott, Alison

机构：

来源：

NATURE | 2008年 / 454卷 / 7201期

关键词：

D O I：

10.1038/454154a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Does the difficulty in finding the genes responsible for mental illness reflect the complexity of the genetics or the poor definitions of psychiatric disorders? Alison Abbott reports.

引用

页码：154 / 157

页数：4

共 7 条

[1] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].

Caspi, A ;

Sugden, K ;

Moffitt, TE ;

Taylor, A ;

Craig, IW ;

Harrington, H ;

McClay, J ;

Mill, J ;

Martin, J ;

Braithwaite, A ;

Poulton, R .

SCIENCE, 2003, 301 (5631) :386-389

[2] Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia [J].

Egan, MF ;

Goldberg, TE ;

Kolachana, BS ;

Callicott, JH ;

Mazzanti, CM ;

Straub, RE ;

Goldman, D ;

Weinberger, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6917-6922

[3] Serotonin transporter genetic variation and the response of the human amygdala [J].

Hariri, AR ;

Mattay, VS ;

Tessitore, A ;

Kolachana, B ;

Fera, F ;

Goldman, D ;

Egan, MF ;

Weinberger, DR .

SCIENCE, 2002, 297 (5580) :400-403

[4] Disruption of two novel genes by a translocation co-segregating with schizophrenia [J].

Millar, JK ;

Wilson-Annan, JC ;

Anderson, S ;

Christie, S ;

Taylor, MS ;

Semple, CAM ;

Devon, RS ;

St Clair, DM ;

Muir, WJ ;

Blackwood, DHR ;

Porteous, DJ .

HUMAN MOLECULAR GENETICS, 2000, 9 (09) :1415-1423

[5] ASSOCIATION WITHIN A FAMILY OF A BALANCED AUTOSOMAL TRANSLOCATION WITH MAJOR MENTAL-ILLNESS [J].

STCLAIR, D ;

BLACKWOOD, D ;

MUIR, W ;

CAROTHERS, A ;

WALKER, M ;

SPOWART, G ;

GOSDEN, C ;

EVANS, HJ .

LANCET, 1990, 336 (8706) :13-16

[6] Genomewide association for schizophrenia in the CATIE study: results of stage 1 [J].

Sullivan, P. F. ;

Lin, D. ;

Tzeng, J-Y ;

van den Oord, E. ;

Perkins, D. ;

Stroup, T. S. ;

Wagner, M. ;

Lee, S. ;

Wright, F. A. ;

Zou, F. ;

Liu, W. ;

Downing, A. M. ;

Lieberman, J. ;

Close, S. L. .

MOLECULAR PSYCHIATRY, 2008, 13 (06) :570-584

[7] Strong association of de novo copy number mutations with sporadic schizophrenia [J].

Xu, Bin ;

Roos, J. Louw ;

Levy, Shawn ;

Van Rensburg, E. J. ;

Gogos, Joseph A. ;

Karayiorgou, Maria .

NATURE GENETICS, 2008, 40 (07) :880-885

← 1 →